SCATE
SCATE: Single-cell ATAC-seq Signal Extraction and Enhancement
Bioconductor version: Release (3.17)
SCATE is a software tool for extracting and enhancing the sparse and discrete Single-cell ATAC-seq Signal. Single-cell sequencing assay for transposase-accessible chromatin (scATAC-seq) is the state-of-the-art technology for analyzing genome-wide regulatory landscapes in single cells. Single-cell ATAC-seq data are sparse and noisy, and analyzing such data is challenging. Existing computational methods cannot accurately reconstruct activities of individual cis-regulatory elements (CREs) in individual cells or rare cell subpopulations. SCATE was developed to adaptively integrate information from co-activated CREs, similar cells, and publicly available regulome data and substantially increase the accuracy for estimating activities of individual CREs. We demonstrate that SCATE can be used to better reconstruct the regulatory landscape of a heterogeneous sample.
Author: Zhicheng Ji [aut], Weiqiang Zhou [aut], Wenpin Hou [cre, aut] 
, Hongkai Ji [aut]
Maintainer: Wenpin Hou <wp.hou3 at gmail.com>
citation("SCATE")):
Installation
To install this package, start R (version "4.3") and enter:
if (!require("BiocManager", quietly = TRUE))
install.packages("BiocManager")
BiocManager::install("SCATE")For older versions of R, please refer to the appropriate Bioconductor release.
Documentation
To view documentation for the version of this package installed in your system, start R and enter:
browseVignettes("SCATE")| 1. SCATE package | HTML | R Script |
| Reference Manual | ||
| NEWS | Text | |
| LICENSE | Text |
Details
| biocViews | ExperimentData, ExperimentHub, Genome, SNPData, SequencingData, SingleCellData, Software |
| Version | 1.10.0 |
| In Bioconductor since | BioC 3.12 (R-4.0) (3 years) |
| License | MIT + file LICENSE |
| Depends | parallel, preprocessCore, splines, splines2, xgboost, SCATEData, Rtsne, mclust |
| Imports | utils, stats, GenomicAlignments, GenomicRanges |
| Linking To | |
| Suggests | rmarkdown, ggplot2, knitr |
| System Requirements | |
| Enhances | |
| URL | |
| Bug Reports | https://github.com/Winnie09/SCATE/issues |
See More
| Depends On Me | |
| Imports Me | |
| Suggests Me | |
| Links To Me | |
| Build Report |
Package Archives
Follow Installation instructions to use this package in your R session.
| Source Package | SCATE_1.10.0.tar.gz |
| Windows Binary | SCATE_1.10.0.zip |
| macOS Binary (x86_64) | |
| macOS Binary (arm64) | SCATE_1.9.0.tgz |
| Source Repository | git clone https://git.bioconductor.org/packages/SCATE |
| Source Repository (Developer Access) | git clone git@git.bioconductor.org:packages/SCATE |
| Bioc Package Browser | https://code.bioconductor.org/browse/SCATE/ |
| Package Short Url | https://bioconductor.org/packages/SCATE/ |
| Package Downloads Report | Download Stats |